Olympique Lyonnais booked a place in the Coupe de France round of 32 with a 2-0 win away to National 3 side Bourges while Montpellier, Angers and Nîmes all fell to shock defeats - also to lower-league opposition.
Nantes booked their place in the Coupe de France round of 32 with a 4-1 win at home to Domino's Ligue 2 side Châteauroux, while Strasbourg saw their clash away to Grenoble postponed due to freezing conditions.
Paris Saint-Germain have been drawn against Manchester United in the round of 16 of the UEFA Champions League, while Olympique Lyonnais will face Barcelona. Rennes are up against Real Betis in the round of 32 of the UEFA Europa League.
Stade Rennais coach Julien Stéphan hailed his players' progress and maturity after they clinched a place in the UEFA Europa League last 32 with a 2-0 win in their do-or-die clash with FC Astana on Thursday.
Ismaïla Sarr scored twice as Stade Rennais FC clinched their place in the UEFA Europa League knockout stages with a 2-0 win over FC Astana on Thursday, but Girondins de Bordeaux bowed out despite winning in Copenhagen.
OL hero Nabil Fekir underlined his whole team's performance after they clinched a first last-16 berth in seven years 1-1 away to Shakhtar Donetsk, whose coach Paulo Fonseca lauded the OL goal-scorer's abundant talent.
Olympique Lyonnais are through to to UEFA Champions League's last 16 for the first time since 2011, but had to endure some nervy moments before Nabil Fekir struck to clinch a 1-1 draw against Shakhtar Donetsk on Wednesday.
Holders Paris Saint-Germain have been drawn away to fifth-tier opposition in the round of 64 of the Coupe de France, while Toulouse FC will host OGC Nice in the only clash between two top-flight teams.