Olympique de Marseille boss Rudi Garcia vowed to fight on for qualification despite a humiliating 3-1 home loss to Lazio; Bordeaux and Rennes also lamented defeats that cut their qualification chances to the nub.
Angel Di Maria scored with the final act of the game (93') as Paris Saint-Germain twice battled back to hold SS. Napoli to a 2-2 draw at the Parc des Princes in UEFA Champions League Group C on Wednesday.
Moussa Sylla scored for AS Monaco at Club Brugge KV in UEFA Champions League Group A on Wednesday (32'), but Wesley's goal (39') meant Thierry Henry's men had to settle for a share of the spoils in Belgium.
Olympique Lyonnais coach Bruno Génésio was disappointed not to come away from TSG 1899 Hoffenheim with all three points, but remains convinced his side will make it to the UEFA Champions League knock-out stages.
OL were within seconds of a precious win in Hoffenheim - which would have kept them top of Group F - but Joelinton's last-gasp strike earned the German side a share of the points in thrilling, see-sawing 3-3 draw on Tuesday.