Second-half goals from Presnel Kimpembe and Kylian Mbappé gave Paris Saint-Germain a 2-0 win over Manchester United after an outstanding performance in their UEFA Champions League last 16, first leg on Tuesday.
Lyon dominated cup specialists Guingamp 2-1, with goals from Moussa Dembélé and Maxwel Cornet too much for Alexandre Mendy's late retort in their last 16 clash on Thursday. OL face SM Caen at home in the quarters.
Holders Paris Saint-Germain are through to the Coupe de France quarter-finals, but were taken to extra-time by amateur side Villefranche-sur-Saône, while Jordan Siebatcheu was Stade Rennais FC's matchwinner against LOSC.
FC Nantes downed Toulouse 2-0, goals from Kalifa Coulibaly and Anthony Limbombe ensuring progression along with Dijon, who beat D4 side Croix 3-0, and SM Caen, who trumped SC Bastia 5-3 on penalties (2-2).
Amiens SC boss Christophe Pélissier admitted his side have a lot of improving to do before Sunday, when they will run back Thursday's 2-0 Coupe de France loss at home to Lyon in Ligue 1 Conforama's Week 22.
Lyon booked their place in the last 16 with a solid display away to Amiens, Moussa Dembélé and Léo Dubois striking in the first half to clinch a 2-0 win despite losing defender Marçal to a red card just before the break.